To use these Brooks running shoes, simply lace them up and you're ready to hit the road. They're designed for natural running, so just go at your own pace. When it comes to care, it's best to avoid machine washing as it might damage the materials. Instead, use a soft brush and mild soap to gently clean the upper. Let them air dry away from direct heat. If you notice the cushioning feeling less responsive over time, it might be a sign to think about getting a new pair. These shoes are great for regular road running, but don't use them for extreme activities as it could wear them out faster.